סמינר המחלקה להנדסה ביו-רפואית
Modeling and engineering gene expression based on a computational approach: methodology and applications
Gene expression is a process intrinsic to all life, whereby information encoded in the genetic material is used to build proteins that drive the functioning of living organisms. Gene expression is a multi-step process mediated by millions of intracellular biological machines (e.g. RNA polymerases, transcription factors, ribosomes, tRNAs, miRNAs), with complex interactions among them. Deciphering, modelling, and engineering the process of gene expression is therefore an extremely challenging undertaking, but one with enormous potential to impact any biomedical field.
In our lab, we develop various computational models and algorithms that are used in conjunction with state-of-the-art approaches for genome editing to understand and engineer this process. Our pipeline is based among others on biophysical simulations, machine learning, tools from electrical engineering, computer science, and computational molecular evolution.
In recent years these models have been used in various applications such as generating vaccines and oncolytic viruses, producing therapeutic proteins and green energy, generating cheap food ingredients, designing efficient biosensors, and developing novel diagnosis tools based on cancer genomes.
The aim of this seminar is to provide an introduction to the field and to the approaches developed in our lab for mastering gene expression, and to demonstrate the applications of our tools. The talk will be self-contained and will not require prior knowledge.