סמינר מחלקה של אביעד גלר - תגובה מכנית פסיבית ואקטיבית של עורקי יונק פנימיים אנושיים
School of Mechanical Engineering Seminar
Monday April 3.4.2023 at 14:00
Wolfson Building of Mechanical Engineering, Room 206
PASSIVE AND ACTIVE MECHANICAL RESPONSE OF HUMAN INTERNAL MAMMARY ARTERIES
M.Sc. research under the supervision of Prof. Zohar Yosibash
Computational Mechanics & Experimental Biomechanics Lab
School of Mechanical Engineering, Tel Aviv University, Israel
Coronary artery disease (CAD) is the most common cardiovascular disease resulting in more than 365,000 deaths in the US in 2017. A coronary artery bypass graft (CABG), a bypass sutured to the constricted coronary artery, is a common clinical procedure to overcome CAD. The most common artery used as a CABG is the internal mammary arteries (IMA). Therefore, the study of the mechanical behavior of the IMA arterial wall is highly important. We investigated experimentally the biomechanical response of such arteries. These are characterized by a passive response related to the collagen fibers and elastin fibrils and an active response due to smooth muscle cells (SMCs) contraction. Such experiments on human IMAs are scarce and are mandatory to verify and validate constitutive models that may predict the passive and mainly their active responses.
We present a series of eighteen experiments on the passive response of human IMAs, harvested during CABG surgeries. The preconditioning protocol is studied as well as a new method for determining the physiological axial stretch. Lastly, experimental results on the passive response while inflating the arteries from 20 to 200mmHg are presented.
A second study of five experiments was conducted aiming at stimulating the smooth muscle cells to investigate the active response. We were unable to measure properly the active response so a series of five ring-tests were performed to focus on the reaction of the artery to vasoconstrictors. The active response recorded was significant although counterintuitive.
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