סמינר של ד"ר אסף זינגר

Unlocking the Cellular Blueprint- Precision Targeting of Diseased Tissues with Biomimetic Nanoparticles

Biomimetic nanoparticles aim to emulate the behavior of either cells or exosomes effectively. For example, leukocyte-based biomimetic nanoparticles incorporate cell membrane proteins to transfer the natural tropism of leukocytes to the final delivery platform.

Here, I will demonstrate how tweaking the protein content improved the targeting of inflamed endothelium in three different preclinical models and describe the imaging challenges that arose in these projects.

I will also discuss the reproducible production of two types of neuron-targeting biomimetic nanoparticles, each with a distinct lipid formulation backbone suited to potential therapeutic cargo (e.g., mRNA, small molecules, and protein), by integrating membrane proteins unbiasedly sourced from human pluripotent stemcell-derived neurons4.

Our combined use of a microfluidic, bottom-up approach and tuning of key synthesis parameters enabled the synthesis of reproducible5, enhanced biomimetic nanoparticles that have the potential to improve the treatment of inflammatory-based conditions and genetic disorders through targeted nano delivery.