סמינר

Prof.Jacques Ohayon

Professor of Mechanical Engineering

1 Laboratory TIMC-DyCTiM, University Joseph-Fourier, CNRS UMR 5525, In3S, Grenoble, France

2 Engineering School Polytech Annecy-Chambיry, University of Savoie Mont-Blanc, Chambיry, France

Email: Jacques.Ohayon@imag.fr

Website: http://membres-timc.imag.fr/Jacques.Ohayon/

Biomechanics of Coronary Atherosclerotic Plaque Rupture:

Progress, Challenges and New Directions

The aims of Prof. Ohayon’s research on Cardiovascular Biomechanics are to understand the

evolution of atherosclerotic plaque vulnerability and to increase knowledge of the plaque

growth process through the combined use of mechanical modeling based on the nonlinear

continuum mechanics theory, finite element method, together with clinical, pathologhical and

biological investigations. On 2009, his group demonstrating that it was possible to reconstruct

fully automatically the elasticity map of an atherosclerotic plaque based on an in vivo

intravascular ultrasound sequence. On 2011, Dr Ohayon underlined, for the first time, the

importance of local arterial wall stiffness in the development of atherosclerosis and showed that

arterial wall-strain stiffening might, in addition to low endothelial shear stress, be a precondition

for the development of atherosclerosis. Today, he coordinates an interdisciplinary international

scientific consortium (Canada-Spain-France-Japan-Switzerland-USA) on the Biomechanics of

Atherosclerosis Plaque that he initiated in 2007 and with which he already published more than

40 collaborative studies.

Abstract of his presentation: The leading cause of major morbidity and mortality in most

countries around the world is atherosclerotic cardiovascular disease, most commonly caused by

the rupture of a vulnerable plaque (VP). The challenge for the new generation of in vivo clinical

imaging methods is that prediction of the VP rupture requires not only an accurate description

of plaque morphology, but also a precise knowledge of mechanical properties of plaque

constituents. Indeed, such knowledge will likely allow a precise evaluation of the thin-cap fibroatheroma

peak stress amplitude, which is a reliable predictor of VP rupture. The clinical success

of a surgical intervention depends on knowledge of whether a lesion is at risk for rupture and

can be responsible for the development of neurological or cardiovascular events, respectively.

The medical history and paraclinical tests are sometimes insufficient to resolve this uncertainty.

Hence, it is essential to develop, test and validate novel invasive and noninvasive clinical

diagnostic methods based on continuum mechanics theory combining strain and elasticity

reconstruction techniques for a better in vivo evaluation of the risk of vulnerable carotid and

coronary plaque ruptures. The proposed imaging method appears promising for the evaluation

of VP rupture. Furthermore, the performance for the stabilization of VP using new treatment

strategies could be investigated by using such imaging technique.

ההרצאה תתקיים ביום שלישי 24.11.15.

נפגש ב 13:45 לשיחה וכיבוד, ההרצאה תחל בשעה 14:00

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