Abstract: Self-assembling peptides offer great potential as versatile building blocks for developing functional hydrogels suitable for various applications.
This presentation will focus on the mussel inspired design of peptide-based antibacterial hydrogels.
These bioinspired materials combat bacteria through a dual mechanism involving surface-contact membrane disruption and oxidative killing facilitated by hydrogen peroxide (H2O2) production. The leading formulation, MIKA2, has shown its potential as an injectable hydrogel capable of preventing implant-related bacterial infections, effectively reducing bacterial colonization on titanium implants in mice.
