ה ביו רפואית

גיל תמיר

תלמיד המחלקה להנדסה ביו רפואית לתואר שני ירצה בנושא:

3D TEMPERATURE MAPPING FOR MONITORING OF TUMOR'S LOCALIZED HYPERTHERMIA TREATMENT

Tumor treatment procedures span from electron radiation to chemotherapy and surgery. These procedures differ in many aspects involving invasiveness, collateral damage, effectiveness duration, ext. Hyperthermia therapy is a treatment in which the cancerous tissue is exposed to high temperatures to damage and kill cancer cells. A well established localized hyperthermia treatment procedure was proposed by Gannot et.al via the use of Antibody conjugated magnetic Nanoparticles which hold the ability to specifically adhere tumors. Once subjected to an external RF-frequency magnetic field the tumor conjugated MNPs form a localized heat source.

In our current work we present a heat source temperature monitoring method to ensure hyperthermia effectiveness and minimize collateral damage to surrounding tissues.

The temperature monitoring method is based on a heat source (tumor) power estimation algorithm.

A byproduct of the localized hyperthermia is the tissue heat conduction from the embedded tumor (source) to tissue/body physical boundary i.e. skin surface.

Hence while exposing the tissue to external magnetic field, a time dependent temperature pattern/hot spot is captured by a thermal camera facing the skin. Given the geometrical dimensions of the ROI and tissue, ambient thermal properties the ill-posed thermal inverse problem is solve.

We show that thermal XY resolution (per depth) improves as stimulation frequency increases even slightly above DC, enabling better heat source XY separation  and margin identification in the case of distributed heat sources.

העבודה נעשתה בהנחיית פרופ' ישראל גנות המחלקה להנדסה ביו-רפואית, אוניברסיטת תל-אביב