Department of Bio medical Engineering seminar
24.11.24 14: 00 315 room interdisciplinary building
Dror Fixler PHD
Nano Photonics and it’s biological applications
During our talk we will deal with theoretical and practical models for reconstructing the optical properties of participating media by nano photonic tools. Our theory is based on a robust generalization of the diffusion theory; Gerchberg-Saxton algorithm; dipole-dipole approximation and other methods. On the practical side we use lasers, LEDs and microscopes.
Human tissue is one of the most complex optical mediums since it is nonhomogeneous. Its optical properties are unknown and vary in different tissue arias and physiological states. Because of all of the above, in vivo imaging is a difficult task. In our lab we deal with this difficulty by focusing on detection rather than imaging. We use methods which probe the tissue properties by means of the diffusion reflection profile, adding nano particles as contrast agent, the full scattering profile and its iso pathlength point or iterative phase multiple measurement reconstruction techniques. Furthermore, we use changes in optical parameters, such as fluorescence lifetime and fluorescence anisotropy to probe the biological surroundings. We are able to fabricate Gold nano particles (spheres and rods), organic nano particles as well as tissue like phantoms. The applications for these methods include diagnosis of diseases such as cancer and atherosclerosis, examination of different physiological parameters, visualizing enzyme activity and early-stage cell mutation detection.
Dror Fixler received his PhD from the Department of Physics, Bar-Ilan University, Ramat Gan, Israel, in 2003. He is the vice dean of the faculty of engineering and ex-director of the Nano Center, Bar-Ilan University. He has published more than 150 original research papers and holds more than 13 issued patents. His research interests include fluorescence measurements (FLIM and anisotropy decay), optical super-resolution, high-end electro-optical system engineering, and light–tissue interaction. He received several international awards and organized and presented at more than 200 international conferences.
