מרב קטלוניה
תלמידת המחלקה להנדסה ביו רפואית לתואר שלישי תרצה בנושא:
Effect of Peripheral Electrical Stimulations on Glycemic Control Loop in Diabetes Patients
The epidemic nature of type 2 diabetes mellitus (T2DM), along with the downsides of current treatments, has raised the need for therapeutic alternatives. In this research we evaluated the effect of noninvasive peripheral electrical stimulation (PES) on glucose regulation in preclinical, and clinical pilot studies.
In a preclinical model, we studied normo-glycemic and high-fat diet (HFD), induced insulin-resistant rats for 3 weeks. In addition, the effect of an acute PES treatment on metabolic rates of glucose appearance and turnover was measured by using the hyperinsulinemic–euglycemic clamp test. This study demonstrates that a noninvasive PES treatment of very short duration in rats is sufficiently potent to stimulate glucose utilization, improve hepatic insulin sensitivity, and have a beneficial effect on body weight.
Then, a clinical study was designed to evaluate safety, tolerability, and the glucose-lowering effect of PES treatment in T2DM patients. Twelve patients were recruited for an open label, interventional, randomized trial, and underwent, in a crossover design, an active, and a no-intervention control trial periods. During the active period, the patients received a daily lower extremity PES treatment for 14 days. Endpoints were analyzed based on continuous glucose meter readings, and laboratory evaluation. The study results indicate that repeated PES treatment may suppress hepatic glucose production, and thus, act to maintain basal overnight and fasting glucose concentrations. This effect may be mediated, at least in part, by hypothalamic-pituitary-adrenal axis modulation.
Using mathematical model analysis of systemic glycemic control during nocturnal sleep, we explored possible neuroendocrine mechanisms involved in this therapeutic strategy.
Future studies, including larger populations, and longer follow up periods, are needed to gain better understating of these methods. Once proven over a larger cohort of patients, PES may provide an additional potential treatment strategy for the current solutions available for T2DM patients.
העבודה נעשתה בהנחיית ד"ר אורי נבו מהמחלקה להנדסה ביו-רפואית,
ופרופ' אשל בן-יעקב ז"ל מביה"ס לפיסיקה ואסטרונומיה, אוניברסיטת תל אביב
ההרצאה תתקיים ביום ראשון 26.03.17, בשעה 14:30
בחדר 315, הבניין הרב תחומי, אוניברסיטת תל אביב
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